AFK is commonly used with a descriptor like " afk bio" (you are going to the washroom), or " afk phone" (you are answering a phone call). AFK is. 5 definitions of AFK. Definition of AFK in Slang/Internet Slang. What does AFK stand for?. I have heard my friend talk about being AFK on a Minecraft server, but AFK is an acronym for "away from keyboard". It's commonly used in.